Fat

More evidence that 'healthy obesity' may be a myth

The term "healthy obesity" has gained traction over the past 15 years, but scientists have recently questioned its very existence. A study published August 18 in Cell Reports provides further evidence against the notion of a healthy obese state, revealing that white fat tissue samples from obese individuals classified as either metabolically healthy or unhealthy actually show nearly identical, abnormal changes in gene expression in response to insulin stimulation.
"The findings suggest that vigorous health interventions may be necessary for all obese individuals, even those previously considered to be metabolically healthy," says first author Mikael Rydén of the Karolinska Institutet. "Since obesity is the major driver altering gene expression in fat tissue, we should continue to focus on preventing obesity."

http://medicalxpress.com/news/2016-08-evidence-healthy-obesity-myth.html

More information: Cell Reports, Rydén et al.: "The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity" http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31014-2 , DOI: 10.1016/j.celrep.2016.07.070 

ETA:  My LLMD thinks that Lyme / Borrelia infections may be a direct cause of obesity, which is rarely diagnosed.   I concur strongly.